Table 1. Clinical characteristics and responses of L-CTCL patients.
Characteristics | Patients (n=18) |
---|---|
Age - Years old | |
Median | 67.0 |
Range | 54.0 – 79.0 |
| |
Gender - no. of patients (%) | |
Female | 5 (27.8%) |
Male | 13 (72.2%) |
| |
Stage - no. of patients (%) | |
III | 2 (11.1%) |
IV | 16 (88.9%) |
| |
Modified skin-weighted assessment tool (mSWAT) | |
≤ 5.0 | 1(5.5%) |
39.0– 80.0 | 10 (55.6%) |
≥ 80.0 | 7 (38.9%) |
| |
Blood involvement * | |
B1: low blood tumor burden | 4 (22.2%) |
B2: high blood tumor burden | 14 (77.8%) |
| |
TCR vβ - no. of patients (%) | |
Positive | 16 (88.9%) |
Negative | 2 (11.1%) |
| |
ECP - no. of cycles** | |
Median | 9.5 |
Range | 6 - 13 |
| |
Combination immunotherapy - no. of patients (%) | |
ECP alone | 6 (33.3%) |
+ Bexarotene | 5 (27.8%) |
+ IFN-α | 2 (11.1%) |
+ Bexarotene and IFN-α | 5 (27.8%) |
| |
Response - no. of patients (%) | |
Partial response (PR) | 8 (44.4%) |
Minor response (MR) | 4 (22.2%) |
Stable disease (SD) | 3 (16.7%) |
Progressive disease (PD) | 3 (16.7%) |
: circulating CD4+CD26- or CD4+CD7- T-cells;
: excluding Patient#8 who had L-CTCL plus GVHD