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. Author manuscript; available in PMC: 2016 Jun 29.
Published in final edited form as: Adv Drug Deliv Rev. 2015 Apr 14;87:35–45. doi: 10.1016/j.addr.2015.04.005

Figure 1. Pathways of Endocytosis and Trafficking.

Figure 1

The figure illustrates several of the major internalization and trafficking pathways discussed in the text. Phagocytosis takes places only in specialized cells such as macrophages and granulocytes while the uptake pathways illustrated here are found in many cell types. A few of the key proteins or protein complexes involved in some of the pathways are indicated; however many other essential proteins are not depicted. Specific Rab GTPases play key roles controlling the flow of vesicles between individual compartments. The role of the Retromer complex in endosome to Golgi traffic and the role of the ESCRT complex in the formation of MVBs are discussed in the text. (figures adapted with modification from reference 89).