Table 2.
Multivariate structural brain signatures
| Brain Signature 1 | Brain Signature 2 | Brain Signature 1 | Brain Signature 2 | ||
|---|---|---|---|---|---|
| Region | Metric | Loading | Loading | VIP | VIP |
| L Paracentral lobule and sulcus | MC | −0.28 | 1.49 | 0.99 | |
| L Postcentral gyrus | CT | −0.43 | 2.30 | 1.53 | |
| L Postcentral gyrus | V | −0.28 | 1.47 | 0.98 | |
| L Precentral gyrus | V | −0.26 | 1.35 | 0.90 | |
| R Central sulcus (Rolando’s fissure) | MC | −0.26 | 1.36 | 0.91 | |
| R Paracentral lobule and sulcus | MC | −0.22 | 1.17 | 0.78 | |
| R Precentral gyrus | MC | −0.33 | 1.72 | 1.15 | |
| R Superior segment of the circular sulcus of the insula (anterior/ mid insula) | MC | −0.19 | 1.01 | 0.67 | |
| L Middle temporal gyrus | V | −0.21 | 1.13 | 0.75 | |
| L Precentral gyrus | MC | −0.19 | 1.00 | 0.67 | |
| R Superior part of the precentral sulcus | MC | −0.16 | 0.84 | 0.56 | |
| R Superior frontal gyrus | MC | −0.15 | 0.79 | 0.53 | |
| R Pericallosal sulcus (S of corpus callosum) | MC | −0.17 | 0.92 | 0.62 | |
| R Anterior segment of the circular sulcus of the insula | MC | −0.16 | 0.85 | 0.57 | |
| L Subcentral gyrus (central operculum) and sulci | CT | −0.17 | 0.91 | 0.61 | |
| L Middle-posterior part of the cingulate gyrus and sulcus (pMCC) | MC | −0.16 | 0.83 | 0.55 | |
| L Anterior segment of the circular sulcus of the insula | MC | −0.14 | 0.72 | 0.48 | |
| L Central sulcus (Rolando’s fissure) | V | −0.15 | 0.78 | 0.52 | |
| L Suborbital sulcus (sulcus rostrales, supraorbital sulcus) | MC | −0.15 | 0.78 | 0.52 | |
| L Pericallosal sulcus (S of corpus callosum) | MC | −0.13 | 0.71 | 0.47 | |
| L Middle frontal gyrus | MC | −0.12 | 0.61 | 0.41 | |
| R inferior frontal/ anterior insula sulcus | CT | −0.27 | 0.00 | 1.07 | |
| L Superior part of the precentral sulcus | CT | −0.16 | 0.00 | 0.62 | |
| L Subcallosal area, subcallosal gyrus | MC | −0.30 | 0.00 | 1.18 | |
| R Transverse temporal sulcus (primary auditory area near Heschl’s gyrus) | MC | −0.64 | 0.00 | 2.53 | |
| L Lateral occipito-temporal sulcus (fusiform gyrus) | SA | 0.33 | 0.00 | 1.31 | |
| L Intraparietal sulcus (interparietal sulcus) and transverse parietal sulci | MC | −0.53 | 0.00 | 2.07 | |
| L Posterior ramus (or segment) of the lateral sulcus (or fissure) | V | −0.12 | 0.00 | 0.46 |
Brain morphometric endophenotypes selected for each brain signature along with variable loadings on that dimension/signature. For brain signature 1, all negative loading reflect IBS >HC. For brain signature 2, negative loading reflect HC > IBS. Variable of importance to the prediction coefficients (VIP) greater than one indicate endophentotypes that are considered particularly important for the classification. Please note these VIP values change for variables comprising the first component when considering the second component due to the additional variance explained.
Morphometric endophenotype indicates whether the measure was mean curvature,(MC), Volume (V), cortical thickness (CT), or surface area (SA). The first brain signature explained 16% of the variability and the second explained an additional 20% variance in classification of IBS based on morphometric phenotype data. Abbreviations L=Left, R=right.