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. Author manuscript; available in PMC: 2016 Jan 31.
Published in final edited form as: J Invest Dermatol. 2015 Mar 19;135(8):2109–2118. doi: 10.1038/jid.2015.110

Figure 5. TGF-β is required for LIGHT driven skin fibrosis.

Figure 5

(a) WT, LIGHT−/−, HVEM−/−, and WT mice treated with anti-LTβR, were challenged with intratracheal bleomycin, and after 7 days skin expression of TGF-β1 mRNA was assessed. Values are mean ± SEM of 3 to 4 mice per group. (b) WT mice, treated with control IgG or anti-TGF-β, were administered 10 μg of rmLIGHT on days 1 and 2. Skin fibrosis and TSLP expression was assessed as before on day 3. Dashed line delineates the basement membrane. Scale bar = μm. Data are representative of 3 individual mice analyzed per group.