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. Author manuscript; available in PMC: 2016 Jul 15.
Published in final edited form as: Bioconjug Chem. 2015 Apr 6;26(7):1224–1236. doi: 10.1021/acs.bioconjchem.5b00070

Figure 6.

Figure 6

Data showing the effects of ligand synergism on platelet adhesion. (A) Synergistic ligands can be incorporated into heteromultivalent liposomes using a mixture of DSPE-PEG-peptide conjugates during liposome synthesis [reproduced with permission from 38]. Liposomes with fixed 5 mol% DSPE-PEG-peptide was synthesized with varying ratios DSPE-PEG-CBP to DSPE-PEG-VBP to determine the optimal ratio for maximizing liposome adhesion to the subendothelial matrix. Liposomes were flowed through a parallel plate fluidic chamber over glass slides coated with 1:1 ratio of vWF to collagen under a range of shear stresses. Adhesion at (B) 5 dynes/cm2, (C) 30 dynes/cm2, and (D) 55 dynes/cm2 was quantified by measuring fluorescence from fluorescently-labeled liposomes [reproduced with permission from 39].