Skip to main content
. Author manuscript; available in PMC: 2016 Jul 15.
Published in final edited form as: Bioconjug Chem. 2015 Apr 6;26(7):1224–1236. doi: 10.1021/acs.bioconjchem.5b00070

Figure 8.

Figure 8

In vitro characterization of PolySTAT-modified fibrin and in vivo evaluation of hemostatic efficacy. (A) PolySTAT is a synthetic poly(HEMA) polymer with multivalent display of fibrin-binding peptides (shown in red). (B) PolySTAT-modified fibrin has a denser mesh structure compared to control fibrin (SEM scalebar = 10 μm). Intravenous injection of PolySTAT in a rat femoral injury model significantly (C) increases survival rate and (D) reduces hemorrhage rate [reproduced with permission from 88].