Fig. 6.

Pendrin gene ablation reduces ENaC subunit abundance more in mice harboring WT ENaC than those with the Liddle's ENaC mutation. A: representative blots showing ENaC subunit abundance in kidney lysates taken from mice in each group described in Fig. 5. B: relative band density of α-, β-, and γ-subunits of ENaC in kidney lysates of mice taken from each group. ENaC subunit abundance was compared in aldosterone-treated WT and KO kidneys. For each ENaC subunit, abundance was expressed relative to that observed in the aldosterone-treated WT kidney. Lysates from aldosterone-treated LL/KO and LL/WT mice were also compared. ENaC subunit abundance was expressed relative to that of LL/WT mice. *P < 0.05.