Figure 2.

Peak stimulated serum LH and FSH levels. LH (A) and FSH (B) levels are mean ± SD. Dashed line represents predetermined pubertal response for peak LH (4 mIU/mL) or peak FSH (2.5 mIU/mL) levels. Patients' hormone levels had to be below this level to be considered suppressed. Histrelin treatment period (treatment) as well as posttreatment follow-up (6-month follow-up) is indicated. Pretreated and naive patients, as well as the two groups combined, are indicated. *, P ≤ .0001; †, P < .001; ‡, P < .01; §, P < .05 combined patient group vs baseline.