Fig. 5.
Effects of nNOS inhibition with S-methyl thiocitrulline (SMTC) on log dose-response effects of testosterone (TES) infusions on mean arterial blood pressure (MAP) in conscious, unrestrained, chronically catheterized, ganglion-blocked male Sprague-Dawley rats (0.375–6.00 μmol·kg−1·min−1 iv; 0.15 ml·kg−1·min−1), pretreated with SMTC (TES+SMTC, 20 μg·kg−1·min−1; n = 5 rats) or not (TES; n = 8 rats). Rats were pretreated with SMTC for 30 min before and then during TES infusions. Data points are means ± SE. MAP differed significantly with dose of TES (P = 0.0009) but not with dose of TES+SMTC (P = 0.0930). Effects of TES on MAP differed between TES and TES+SMTC at each dose (*0.0027 ≤ P ≤ 0.038).