Fig. 3.

Neuronal excitability to bethanechol following MI is unchanged by ANG II modulators. F-I curves were determined in animals 7 wk after surgical MI induction with and without bethanechol application in animals with MI alone (n = 37 cells), or combined with 6 wk of treatment with captopril (n = 25 cells), losartan (n = 30 cells), or CGP42112A (n = 37 cells). MI does not alter neuronal excitability with bethanechol application over control animals (A; *P < 0.05 vs. both control and MI control at that stimulus intensity). The same MI with bethanechol data is shown in B–D for comparison. None of the AT-related drug treatments produced any significant differences in bethanechol sensitivity vs. MI alone (*P < 0.05 vs. control at each stimulus intensity using Kruskal-Wallis ANOVA on ranks).