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ANG II modulates output frequency by AT1R stimulation. Synaptic efficacy was determined at 20-Hz stimulation for 2 s in control animals with and without 100 nM ANG II in the bath solution. ANG II significantly reduced the output frequency (*P < 0.05, Friedmans repeated-measures ANOVA on ranks). Losartan (1 μM) in the bath solution inhibited the effects of ANG II on output frequency (n = 4). Bars represent the means ± SE.
