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Nitrite therapy with sustained release SR-nitrite significantly reduced myocardial oxidative stress and increased antioxidant enzyme mRNA levels in obese OS after CLI. A–F: MDA (A), carbonyl protein (B), GPx-1 (C), SOD1 (D), catalase (E), and SOD2 (F) mRNA levels in the hearts of CLI + placebo- and CLI + SR-nitrite-treated pigs. Values are means ± SE; numbers inside bars are numbers of animals per group.
