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A–H: hemodynamic and temperature responses to systemic and leg heat stress combined with leg cooling (Study 1). Leg and systemic hemodynamic and temperature responses over 1 h of passive heat stress with simultaneous isolated cooling of a single leg are shown. Values are means ± SE for 8 participants except for cardiac output (n = 7) and core temperature (n = 6). *Significantly different from baseline; #significantly different from comparable measurement in the cooled leg. P < 0.05.
