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. 2015 May 8;309(2):H297–H304. doi: 10.1152/ajpheart.00079.2015

Fig. 5.

Fig. 5.

Relaxation responses to BAY 58–2667 (an sGC activator) in mesenteric resistance arteries from Wistar and GK rats. A: mesenteric resistance arteries from female GK rats (n = 9) had reduced relaxation responses to BAY 58–2667 compared with arteries from Wistar rats (n = 7) (*P < 0.05, Wistar vs. GK). Inhibition of sGC by ODQ (10−6 M) caused a rightward shift in the BAY 58–2667 concentration-response curves in arteries from Wistar (n = 6) rats (B) and a leftward shift in arteries from GK rats (n = 6) (C) (#P < 0.05, BAY 58–2667 plus vehicle vs. BAY 58–2667 plus ODQ). D: BAY 58–2667 pEC50 was reduced in control arteries (vehicle treated) from GK rats (n = 9) compared with vehicle-treated Wistar arteries (n = 7). Inhibition of sGC by ODQ had differential effects on GK (n = 6) and Wistar (n = 6) arteries such as that ODQ treatment increased pEC50 in GK arteries and increased pEC50 in Wistar arteries (*P < 0.05, Wistar vs. GK; #P < 0.05, BAY 58–2667 plus vehicle vs. BAY 58–2667 plus ODQ).