Fig. 7.
Concentration-response curves to sildenafil [a phosphodiesterase 5 (PDE5) inhibitor] and protein levels of PDE5A in mesenteric resistance arteries from female Wistar and GK rats. A: mesenteric arteries from GK rats (n = 8) had greater relaxation responses to sildenafil compared with arteries from Wistar rats (n = 6). Inset: group comparisons for sildenafil pEC50. (*P < 0.05, Wistar vs. GK). B: protein levels of PDE5 were lower in mesenteric arteries from GK rats (*P < 0.05, Wistar vs. GK; n = 6/group).