Fig. 6.
Fourteen days postchallenge, influenza fails to exacerbate Staphylococcus aureus coinfection. Mice were challenged with influenza A/PR/8/34 (100 pfu) or vehicle for 14 days followed by infection with S. aureus (1 × 108 cfu) for 24 h. SA, S. aureus only; FLU/SA, influenza and S. aureus; FLU, influenza only. A: bacterial burden in the lung (n = 12). B: bronchoalveolar lavage inflammatory cells (n = 12). C and D: inflammatory cytokines in lung homogenate (n = 12). *P < 0.05 vs. FLU; †P < 0.05 vs. FLU/SA; ‡P < 0.05 vs. FLU and SA.