Table 1.

Genes with ≥2-fold increase or decrease in expression under IL-6 trans-signaling vs. classical IL-6 signaling

	IL-6Trans-signaling			Classical IL-6 Signaling
Gene	Log2 FC	P value	FDR P value	Log2 FC	P value	FDR P value
SOCS3	2.40	3.5 × 10−6	0.008	1.15	0.004	*
PLA2G2A	2.40	1.4 × 10−5	0.017	0.96	0.023	*
STEAP2	1.74	0.00015	0.08	0.58		*
STEAP1	1.70	0.01	*	0.70		*
TEX29	1.70	7.6 × 10−5	0.06	0.54		*
AGT	1.66	0.005	*	0.92		*
APLN	1.56	0.0006	*	0.48		*
C10orf10	1.48	1.0 × 10−5	0.014	0.71	0.007	*
SLC39A8	1.45	0.003	*	0.36		*
FAM167B	1.39	2.5 × 10−6	0.007	0.73	0.0017	*
SNED1	1.37	0.004	*	0.61		*
STEAP4	1.33	0.006	*	0.40		*
IL6	1.30	0.005	*	0.22		*
MUC1	1.30	3.3 × 10−8	0.0003	0.55	0.0006	*
WWC1	1.29	1.9 × 10−6	0.006	0.36		*
BCL3	1.28	0.0001	0.07	0.70	0.012	*
JUNB	1.27	0.0003	*	0.68	0.025	*
SOD2	1.27	0.006	*	0.42		*
PTX3	1.25	0.05	*	0.35		*
CA12	1.24	0.002	*	0.46		*
NNMT	1.23	3.3 × 10−8	0.0003	0.34	0.013	*
KIAA0226L	1.23	0.0009	*	0.42		*
C3	1.22	0.004	*	0.52		*
NAMPT	1.21	0.01	*	0.42		*
CEBPD	1.20	2.8 × 10−5	0.03	0.43		*
SBNO2	1.17	6.5 × 10−5	0.05	0.59	0.016	*
PCBP3	1.15	0.00055	*	0.47		*
ANGPTL4	1.13	0.006	*	0.34		*
IFI30	1.13	0.0005	*	0.43		*
KIAA1199	1.09	0.01	*	0.44		*
PDPN	1.08	0.0002	*	0.35		*
GREM1	1.08	0.004	*	0.41		*
OSMR	1.06	9.3 × 10−6	0.013	0.38	0.035	*
TUBB3	1.03	0.0007	*	0.64	0.02	*
RARRES3	1.02	5.2 × 10−6	0.009	0.47	0.007	*
IL13RA1	1.01	0.00056	*	0.31		*
GDF10	−1.02	0.0004	*	−0.24		*
SCN7A	−1.16	0.007	*	−0.71		*
SDPR	−1.32	0.05	*	−0.50		*
CCL11	−1.52	0.009	*	−0.24		*

^*False discovery rate (FDR) P value >0.09. FC, fold change.