Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Scheme summarizing the dynamic changes in the HCN4 IR that occur along the thermodynamic cycle for the coupling between tetramerization and cAMP binding (Fig. 1c). Dashed lines denote segments that are at least partially unstructured and highly dynamic. The β-subdomain is denoted as “β” and remains largely invariant across the thermodynamic cycle. For the sake of clarity, only the most populated in/out topologies are shown for the N3A motif. Further details are available in Table 3.
