FIGURE 10.
ATRA-dependent regulation of genes belonging to the NOTCH pathway in SKBR3 cells. Schematic diagram of the genes belonging to the NOTCH signal transduction pathway (MetacoreTM). The genes up- and down-regulated by ATRA in SKBR3 cells treated with the retinoid for 12 and 48 h (6) are indicated with blue (down-regulation) and red (up-regulation) solid circles. Genes whose expression is significantly modified by ATRA in the same direction at both 12 and 48 h are marked by a surrounding open red or open blue circle.