FIGURE 6.

JP2 truncations do not have a dominant negative effect on Ca²⁺ transients in wild-type cardiomyocytes. A, representative steady-state Ca²⁺ transients under 1-Hz field stimulation. See the legend of Fig. 5 for the definition of the red lines overlapping on Ca²⁺ imaging. B–D, summary of Ca²⁺ transient amplitude, index of dyssynchronization, and duration of 50% decay (T₅₀) (n = 51, 52, 51, and 61 for Ad-Empty, Ad-JP2, Ad-JP2(1–565), and Ad-JP2(566-end), respectively). E, summary of SR Ca²⁺ content, which was assessed by caffeine-induced SR Ca²⁺ release (n = 24, 24, 29, and 33 for Ad-Empty, Ad-JP2, Ad-JP2(1–565), and Ad-JP2(566-end), respectively).