FIGURE 5.

Effect of Pb exposure on bone volume and quality in vertebrae of SOST knock-out mice. Top, images are representative transverse sections from each control and Pb-exposed group in WT and SOST-KO mice. Bar: 200 μm. Bottom, trabecular bone was analyzed in the fourth lumbar vertebra in 6-month-old mice for the following bone parameters: BV/TV, Tb.N, and Tb.Sp. Pb decreased bone mass and bone properties in WT mice. Bone in KO mice was unaffected by Pb. Data represent mean ± S.E. of 5 mice/group. *, p < 0.05, **, p < 0.005 versus 0 Pb WT.