TABLE 1.

Levels of bone Pb (ng Pb/mg of dry tibial bone) and serum Wnt antagonists sclerostin (pg/ml) and DKK1 (ng/ml) in male WT and SOST-KO mice at 3 months

Pb was determined in mineralized tissue by atomic absorption. Data represent mean ± S.E. for 5 mice/group.

Bone Pb	0 ppm of Pb	50 ppm of Pb	200 ppm of Pb
Wild type	0.61 ± 0.18	29.11 ± 8.39a	110.09 ± 4.05a
SOST-KO	0.79 ± 0.26	81.70 ± 10.46b,c	129.68 ± 13.85b
Sclerostin
Wild type	367.8 ± 27.5	342.4 ± 22.8	553.8 ± 91.7a
SOST-KO	N/A	N/A	N/A
DKK1
Wild type	6.98 ± 4.29	25.07 ± 12.25d	35.88 ± 8.59a
SOST-KO	5.73 ± 1.29	22.21 ± 20.62	31.63 ± 27.07e

^a p < 0.005 versus 0 Pb WT.

^b p < 0.005 versus 0 Pb KO.

^c p < 0.05 versus 50 Pb WT.

^d p < 0.05 versus 0 Pb WT.

^e p < 0.05 versus 0 Pb KO.