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. 2015 Jul 17;6:110. doi: 10.3389/fendo.2015.00110

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Copyright © 2015 Banerjee and Mahale.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Partial sequence of the human FSHR showing the TMD. The seven alpha helices, shown as cylinders designated, I–VII, are connected by means of three ELs and three ILs and ends in a short C-tail. Shaded residues () are naturally occurring mutations, (■) indicates residues crucial for cell surface receptor trafficking, ★) indicates residues important for FSH binding, (▲) indicates residues important for FSH-induced cAMP production, (#) indicates residues crucial for internalization of FSH-FSHR complex, and (●) indicates SNP. Explanation for each of these residues is provided in the text wherever applicable. The numbering system followed is according to that for the mature receptor without the 17 amino acid residue signal peptide. The numbers in parentheses correspond to the amino acid residue number including the signal peptide. The ECD comprising residues 1–349 is not shown.

Inline graphic — Partial sequence of the human FSHR showing the TMD. The seven alpha helices, shown as cylinders designated, I–VII, are connected by means of three ELs and three ILs and ends in a short C-tail. Shaded residues () are naturally occurring mutations, (■) indicates residues crucial for cell surface receptor trafficking, ★) indicates residues important for FSH binding, (▲) indicates residues important for FSH-induced cAMP production, (#) indicates residues crucial for internalization of FSH-FSHR complex, and (●) indicates SNP. Explanation for each of these residues is provided in the text wherever applicable. The numbering system followed is according to that for the mature receptor without the 17 amino acid residue signal peptide. The numbers in parentheses correspond to the amino acid residue number including the signal peptide. The ECD comprising residues 1–349 is not shown.