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. 2015 Jul 17;9:272. doi: 10.3389/fncel.2015.00272

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Copyright © 2015 Baltz and Voigt.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The excitability undergoes slow changes in networks with intact GABAergic synaptic transmission. (A) Spontaneous population activity of a 22 DIV old cortical culture. The amount of spike activity undergoes recurrent, spontaneous slow changes over time. (B) (Top) The same culture as in (A) during a 1 h stimulation period, at 1 Hz. (Bottom) A 20-min long period is shown enlarged. The gray scale graph shows the evoked responses ranging from 50 ms before up to 500 ms after each stimulation pulse, temporally aligned to the line graph above. The arrow denotes the time point of stimulation. Trial-averaged population response is shown on the right. (C) Trial-averaged population response of the network during 2 min long time intervals (black: response during the indicated interval; gray: all trials). (D) Spontaneous activity of the culture in (A–C) after the stimulation experiment.