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. 2015 Jul 17;9:272. doi: 10.3389/fncel.2015.00272

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Copyright © 2015 Baltz and Voigt.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Slow changes of the spontaneous network activity are mediated by GABA_Aergic synaptic transmission. (A) Spontaneous population activity of a 22 DIV old cortical culture under control conditions. The line-graph indicates the global firing rate, which is defined as the number of detected spikes through all electrodes per time unit (second). The slow change of the overall network activity was abolished by an (B) acute blockade of GABA_ARs (bicuculline, 5 μM).