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. 2015 Jul 17;9:272. doi: 10.3389/fncel.2015.00272

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Copyright © 2015 Baltz and Voigt.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Responses to prolonged electrical stimulation. (A) The top graph shows the trial average of the population responses to electrical stimulation at 1 Hz. The early responses are cut off at 0.5. The gray scale graph below shows the population responses for each stimulation pulse (trials that fall within a network burst were not considered and were omitted). Each gray dot reflects the number of evoked spikes for a 1-ms wide bin. The graph is sorted by the number of evoked spikes. Note that virtually all activity in the network is time-locked to the stimulation pulses. (B) Same as (A) except for a culture with chronically blocked GABA_ARs. (C) Distribution of the number of evoked spikes during prolonged electrical stimulation. Cultures were stimulated for one hour at 1 Hz under control conditions and (D) with chronically blocked GABA_ARs. Similar results were obtained in six cultures per group aged between 22 and 36 DIV (see main text for details). The bin width is five spikes.