Table 2.

Deprotection and alkylation of cyanoethyl-protected thiol moieties on MPTTFs using CsOH·H₂O or DBU.

Substrate (R1)	RX	Product	Base and conditions	% Yield
4b (SEt)	20-I	4i	CsOH·H2O, THF, MeOH, rt, 16 h	92 (lit. 88 [45])
			DBU, THF, reflux, 20 h	90
4a (SMe)	20-I	4j	CsOH·H2O, THF, MeOH, rt, 2.5 h	87
			DBU, THF, reflux, 18 h	91
4a (SMe)	21-Br		CsOH·H2O, THF, MeOH, rt, 20 h	53
4a (SMe)	21-I		DBU, THF, reflux, 17 h	93
4a (SMe)	22-I		CsOH·H2O, THF, MeOH, rt, 18 h	88
			DBU, THF, reflux, 3 d	92