TABLE 1.
Patient demographics
| Patient parameter | Result(s)a |
Pb | ||
|---|---|---|---|---|
| Group 1 (n = 22) | Group 2 (n = 33) | All patients (n = 55) | ||
| Male/female, n (%) | 14/8 (64/36) | 29/4 (88/12) | 43/12 (78/22) | 0.035 |
| Age, yr, median (IQR) | 36 (24–43) | 44 (30–57) | 39 (29–51) | 0.052 |
| Wt, kg | 56.5 (16.6) | 65.9 (15.6) | 62.2 (16.5) | 0.011 |
| Lean body mass, kg | 52.2 (10.6) | 61.8 (8.8) | 58.0 (10.6) | 0.001 |
| Ht, m | 1.70 (0.09) | 1.73 (0.08) | 1.72 (0.08) | 0.115 |
| Body mass index, kg/m2 | 19.7 (5.8) | 22.0 (5.0) | 21.1 (5.4) | 0.037 |
| Body surface area, m2 | 1.63 (0.22) | 1.80 (0.21) | 1.74 (0.23) | 0.012 |
| Dose, mg | 614 (130) | 595 (26.1) | 602 (84.1) | 0.844 |
| Dose/wt, mg/kg | 11.4 (3.2) | 9.40 (1.8) | 10.2 (2.6) | 0.008 |
| Ethnicity, n (%) | 0.081c | |||
| Black | 11 (50) | 10 (30) | 21 (38) | |
| Caucasian | 4 (18) | 14 (42) | 18 (33) | |
| Asian | 1 (5) | 5 (15) | 6 (11) | |
| Other | 6 (27) | 4 (12) | 10 (18) | |
| Type of tuberculosis, n (%): | 0.089c | |||
| Pulmonary | 12 (55) | 27 (82) | 39 (71) | |
| Extrapulmonary | 6 (27) | 4 (12) | 10 (18) | |
| Both | 4 (18) | 2 (6) | 6 (11) | |
| Comorbidity, present n (%) | 4 (18) | 13 (39) | 17 (31) | 0.095c |
| Comedication, present n (%) | 7 (32) | 26 (79) | 33 (60) | 0.000c |
| Samples/patient, n (%) | 6.5 (1.3) | 10.3 (0.9) | 8.8 (2.2) | 0.000 |
| Sampling schedule | Predose and random times between 0.5 and 8 h postdose | Predose and 1.0, 1.5, 2.0, 2.5, 3.0, 4.0, 6.0, 8.0, 12.0, and 24.0 h postdose | ||
a
Data are presented as means (SD), unless stated otherwise. IQR, interquartile range.
b
Continuous data from comparisons of groups 1 and 2 were tested using the Mann-Whitney U test.
c
Chi-square test.