TABLE 2.
Noncompartmental pharmacokinetic parameters of rifampina
| Pharmacokinetic parameter | Valuesa |
Pb | ||
|---|---|---|---|---|
| Group 1 (n = 22) | Group 2 (n = 33) | All patients (n = 55) | ||
| AUC0–24 (mg · h/liter) | 35.2 (23.9–109) | 46.3 (13.5–117) | 41.5 (13.5–117) | 0.007 |
| Cmax (mg/liter) | 6.8 (3.5–15.6) | 9.3 (2.4–24.1) | 8.2 (2.4–24.1) | 0.002 |
| Tmax (h) | 2.6 (0.5–4.5) | 2.0 (0.4–5.7) | 2.2 (0.4–5.7) | 0.069 |
| CL/F (liter/h) | 17.5 (10.0–31.5) | 13.0 (4.9–51.3) | 14.7 (4.9–51.3) | 0.013 |
| V/F (liter) | 51.9 (25.5–103) | 41.5 (12.8–182) | 45.4 (12.8–182) | 0.054 |
| t1/2 (h) | 1.9 (0.7–2.4) | 2.2 (1.6–6.6) | 2.1 (0.7–6.6) | 0.559 |
a
Data are presented as geometric mean (range), except for the Tmax data, which are displayed as median (range). AUC0–24, area under the concentration-time curve from 0 to 24 h in milligrams × hour per liter; Cmax, maximum concentration in mg per liter; Tmax, time to maximum concentration in hours; CL/F, apparent clearance in liters per hour; V/F, apparent volume of distribution in liters; t1/2, elimination half-life in hours. F, bioavailability.
b
Data from comparisons of groups 1 and 2 were tested using the Mann-Whitney U test.