TABLE 3.
Final population pharmacokinetic model parametersa
| Pharmacokinetic parameter | Values for all patients (n = 55) |
|---|---|
| CLm/F (liters/h/1.85 m2) | 15.5 (8.0) |
| fr | 0.14 (fixed) |
| V/F (liters/kg LBM) | 0.713 (0.282) |
| ka (1/h) | 1.14 (1.03) |
| Tlag (h) | 0.887 (0.571) |
| F | 1 (fixed) |
a
Data are presented as population mean (SD). Bioavailability (F) was fixed at a value of 1, and the rifampin clearance/creatinine clearance ratio (fr) was fixed at a value of 0.14. CLm/F, apparent metabolic clearance in liters per hour normalized to a body surface area of 1.85 m2; V/F, apparent volume of distribution in liters per kilogram of lean body mass (LBM); ka, absorption rate constant in 1/h; Tlag, lag time in the absorption phase in hours.