. 2015 Jul 16;59(8):4907–4913. doi: 10.1128/AAC.00756-15

TABLE 4.

Pharmacokinetic parameters of group 1 and group 2^a

Pharmacokinetic parameter	Values		P^b
Pharmacokinetic parameter	Group 1 (n = 22)	Group 2 (n = 33)	P^b
CL_m/F (liters/h/1.85 m²)	17.9 (9.1–32.9)	13.8 (5.4–54.3)	0.035
V/F (liters/kg LBM)	0.844 (0.545–1.514)	0.637 (0.325–1.162)	0.002
k_a (1/h)	0.90 (0.22–3.24)	1.33 (0.26–5.37)	0.078
T_lag (h)	1.11 (0.46–2.92)	0.77 (0.30–2.12)	0.017

Data are presented as geometric mean (range). CL_m/F, apparent metabolic clearance in liters per hour normalized to a body surface area of 1.85 m²; V/F, apparent volume of distribution in liters per kg of lean body mass; k_a, absorption constant in 1/h; T_lag, lag time in the absorption phase in hours.

Data from comparisons of groups 1 and 2 were tested using the Mann-Whitney U test.