TABLE 5.

Best-performing optimal sampling strategies for one, two, and three time points

First sampling time point (h)	Second sampling time point (h)	Third sampling time point (h)	Correlation coefficient (r)	Mean predictive error (% bias)	% RMSEa
7			0.83	3.8	27.4
6			0.83	0.5	27.6
8			0.83	5.7	27.9
5			0.81	−4.2	29.0
9			0.81	6.9	29.1
3	10		0.93	−3.2	18.3
2	8		0.92	0.3	18.7
3	9		0.93	−4.4	18.8
2	7		0.92	−2.8	18.8
3	8		0.93	−5.2	19.0
1	3	8	0.96	−0.4	13.2
2	4	10	0.96	−2.7	14.0
2	4	9	0.96	−3.6	14.0
1	3	9	0.96	−0.6	14.2
2	5	14	0.96	−2.3	14.3

^aRMSE, root mean square error.