FIG 5.

Effective combination therapy against biofilm-producing P. aeruginosa and the biofilm-defective pqsA::Tn mutant. Tumor-bearing mice were infected with PA14 WT or pqsA::Tn, and at 48 h p.i., mice were treated with 2.5 mg/kg of colistin and tobramycin alone or in combination. (a) Colistin-tobramycin in combination (CST+TOB). (b) Colistin only (CST). (c) Tobramycin only (TOB). Control mice were injected with 0.9% saline solution as a placebo (PLA). One exemplary experiment out of at least three is presented, with n ≥ 5. *, P < 0.05; **, P < 0.005; ***, P < 0.0005.