TABLE 4.
Antiviral activities of WPR-6 and TNK651 against NNRTI-resistant mutant viruses
| SDM(s) | Cell type | EC50 (μM)a |
||
|---|---|---|---|---|
| WPR-6 | TNK651 | NVP | ||
| K103N | MT-4 | 0.151 ± 0.004 | >10 | ND |
| K103N | TZM-bl | 0.035 ± 0.003 | NDb | >10 |
| Y181C | MT-4 | 0.021 ± 0.001 | 2.398 ± 0.246 | ND |
| Y181C | TZM-bl | 0.022 ± 0.005 | >10 | >10 |
| K103N, Y181C | MT-4 | 0.091 ± 0.013 | >10 | >10 |
| K103N, Y181C | TZM-bl | 0.122 ± 0.011 | >10 | >10 |
a
EC50s were determined by using MT-4 or TZM-bl cells in triplicate; the data presented are mean values ± standard deviations from at least two independent experiments.
b
ND, not determined.