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. 2015 Jul 16;59(8):4577–4583. doi: 10.1128/AAC.05064-14

FIG 2.

FIG 2

Phylogenetic relationships of the mec gene complex and serine recombinase ccr genes. Bar length indicates the number of substitutions per site. (A) Phylogenetic relationships of the mec gene complex (mecI-mecR1-mecC-blaZ) detected in SCCmec XI of S. aureus strain LGA251 (GenBank accession no. FR821779) and SCCmec XI remnant of S. xylosus S04009 (GenBank accession no. HE993884) and those (mecIm-mecR1m-mecB [formerly mecAm]-blaZm) detected in M. caseolyticus strains JCSC7528 (GenBank accession no. AB498758), JCSC5402 (GenBank accession no. AP009486), and JCSC7096 (GenBank accession no. AB498756). (B) Phylogenetic relationship of the ccr genes currently described in macrococci (ccrAm1 and ccrBm1 [SCCmec-like element of M. caseolyticus strain JCSC7096, GenBank accession no. AB498756] and ccrAm2 and ccrBm2 [SCCmecKM45013 of M. caseolyticus strain KM45013, GenBank accession no. HG970732]) and one representative staphylococcal ccr per type (ccrA1 and ccrB1 [SCCmec I of S. aureus strain NCTC10442, GenBank accession no. AB033763], ccrA2 and ccrB2 [SCCmec II of S. aureus strain N315, GenBank accession no. BA000018], ccrA3 and ccrB3 [SCCmec III of S. aureus strain 85/2082, GenBank accession no. AB037671], ccrA4 and ccrB4 [SCCmec VI of S. aureus strain HDE288, Genbank accession no. AF411935], ccrA5 and ccrB5 [SCCmec VII-241 of S. pseudintermedius strain KM241, GenBank accession no. AM904731], ccrB6 [SCCmec X of S. aureus strain JCSC6945, GenBank accession no. AB505630], and ccrC1 [SCCmec VII of S. aureus strain JCSC6082, GenBank accession no. AB373032]).