TABLE 2.
Pharmacokinetics of GSK2140944 after a single subcutaneous dose in a murine (BALB/c) S. aureus lung infection modela
| Model | Dose (mg/kg) | V (liter/kg) | K01 (h−1) | K10 (h−1) | AUC0–∞ (mg · h/liter) | t1/2 (h) | Tmax (h) | Cmax (mg/liter) |
|---|---|---|---|---|---|---|---|---|
| I− | 6.25 | 2.055 | 10.000 | 1.091 | 2.788 | 0.636 | 0.249 | 2.319 |
| 50 | 2.130 | 11.338 | 0.940 | 24.965 | 0.737 | 0.239 | 18.739 | |
| 200 | 3.959 | 11.953 | 0.453 | 111.417 | 1.529 | 0.285 | 44.406 | |
| I+ | 0.78 | 3.172 | 10.156 | 0.515 | 0.478 | 1.345 | 0.309 | 0.210 |
| 6.25 | 2.262 | 4.500 | 0.688 | 4.018 | 1.008 | 0.493 | 1.969 |
a
I−, neutropenic; I+, immunocompetent; V, volume of distribution; K01, transfer rate constant into the central compartment; K10, transfer rate constant out of the central compartment; AUC0–∞, AUC from 0 h to infinity; t1/2, elimination half-life; Tmax, time to maximal concentration; Cmax, maximal concentration.