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(a) Representative dose-dependent membrane permeabilization effects of 6″-thioether TOB analogues with C12 or C14 linear alkyl chains on azole-resistant C. albicans ATCC 64124 (strain B). From top to bottom: PI dye uptake by yeast cells without drug, with POS (62.5 mg/liter), with TOB (125 mg/liter), with C12 (0.5×, 1×, or 2× MIC) or with C14 (0.5×, 1×, or 2× MIC). (b) Quantitative representation of the images shown in panel a.
