TABLE 2.
MICs determined for TOB and its analogues with various alkyl chain lengths (C4 to C14) and for three control antifungal agents (POS, ITC, and FLC) against various yeast strains and filamentous fungi
| Yeast or fungal straina | MIC (mg/liter) for compoundb |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| C4 | C6 | C8 | C10 | C12 | C14 | TOB | POS | ITC | FLC | |
| Yeast strains | ||||||||||
| A | >125 | >125 | >125 | 31.2 | 31.2 | 7.8 | >125 | 0.5 | 0.5 | 62.5 |
| B | >125 | >125 | >125 | 62.5 | 31.2 | 7.8 | >125 | >62.5 | >62.5 | >125 |
| C | >125 | >125 | >125 | 62.5 | 15.6 | 7.8 | >125 | 7.8 | 7.8 | 15.6 |
| D | >125 | >125 | >125 | 125 | 31.2 | 7.8 | >125 | 31.2 | 31.2 | >125 |
| E | >125 | >125 | >125 | 125 | 31.2 | 7.8 | >125 | 31.2 | 31.2 | >125 |
| F | >125 | >125 | >125 | 125 | 15.6 | 7.8 | >125 | 15.6 | 31.2 | 62.5 |
| G | >125 | >125 | >125 | 125 | 31.2 | 7.8 | >125 | 15.6 | 31.2 | 62.5 |
| H | 31.25 | 7.8 | 1.95 | 15.6 | 1.95 | 1.95 | 62.5 | <0.975 | <0.975 | <0.975 |
| Filamentous fungi | ||||||||||
| I | >125 | 125 | 125 | 62.5 | 7.8 | 7.8 | >125 | 0.195 | 0.195 | 62.5 |
| J | 62.5 | 31.2 | 31.2 | 3.9 | 3.9 | 3.9 | 62.5 | ≤1.56 | <1.95 | >125 |
Yeast strains: A, C. albicans ATCC 10231; B, C. albicans ATCC 64124; C, C. albicans ATCC MYA-2876(S); D, C. albicans ATCC 90819(R); E, C. albicans ATCC MYA-2310(S); F, C. albicans ATCC MYA-1237(R); G, C. albicans ATCC MYA-1003(R); H, C. neoformans MYA-895. Note that here the S or R following a strain name indicates that ATCC reports the strain susceptible (S) or resistant (R) to ITC and FLC. Filamentous fungi: I, Aspergillus nidulans ATCC 38163; J, Fusarium graminearum 053.
For yeast strains, MIC-0 values are reported for TOB and its analogues, whereas MIC-2 values are reported for azoles. For filamentous fungi, MIC-0 values are reported for all compounds.