TABLE 2.
MICs of GE2270A, compound 2, and NAI003 against selected Gram-positive bacteria
| Species and strain | MIC (μg/ml) of antibiotic: |
|||
|---|---|---|---|---|
| GE2270A | Compound 2 | NAI003 | Vancomycin | |
| Staphylococcus aureus | ||||
| ATCC 29213 | ≤0.015 | 0.5 | >128 | 1 |
| ND041009 | ≤0.015 | 0.5 | >128 | 1 |
| ND018107 | ≤0.015 | 1 | >128 | 0.25 |
| ND018107 | 0.03 | 1 | >128 | 0.5 |
| ND055710 | 0.03 | 1 | >128 | 0.5 |
| ND055910 | 0.03 | 0.5 | >128 | 1 |
| Staphylococcus epidermidis | ||||
| ND006607 | ≤0.015 | 1 | >128 | 1 |
| ND015007 | 0.125 | 2 | >128 | 2 |
| ND020708 | 0.03 | 0.5 | >128 | 2 |
| ND021208 | 0.03 | 2 | >128 | 2 |
| ND024908 | ≤0.015 | 1 | >128 | 2 |
| ND025708 | 0.03 | 1 | >128 | 2 |
| ND026508 | 0.06 | 4 | >128 | 1 |
| Staphylococcus capitis | ||||
| ND004307 | 0.03 | 2 | >128 | 2 |
| ND018807 | 0.25 | 8 | >128 | 2 |
| Streptococcus agalactiae | ||||
| ND050210 | 2 | >128 | >128 | 0.5 |
| L310 | 2 | 32 | >128 | 0.5 |
| Streptococcus pyogenes | ||||
| L1303 | 0.5 | 2 | >128 | 0.5 |
| L800 | 0.5 | 4 | >128 | 0.5 |
| Streptococcus pneumoniae ATCC 49619 | 0.06 | 0.5 | >128 | 0.25 |
| Enterococcus faecalis | ||||
| VanS L559 | 0.008 | NTa | 0.5 | 0.5 |
| VanA L560 | 0.008 | NT | 0.5 | >128 |
| Enterococcus faecium | ||||
| VanS L568 | 0.015 | NT | 16 | 2 |
| VanA L569 | 0.015 | NT | 4 | >128 |
| Mycobacterium smegmatis mc2155 | 4 | 8 | 4 | NT |
| Micrococcus luteus L108 | ≤0.015 | 1 | >128 | 0.125 |
| Corynebacterium jeikeium | ||||
| L2508 | >128 | >128 | >128 | 1 |
| L2645 | >128 | >128 | >128 | 0.5 |
| Corynebacterium sp. | ||||
| L689 | >128 | >128 | >128 | 1 |
| L691 | >128 | >128 | >128 | 0.5 |
a
NT, not tested.