TABLE 3.
MICs of GE2270A, compound 2, and NAI003 against P. acnes
| Propionibacterium acnes strain | MIC (μg/ml) of antibiotic: |
||||
|---|---|---|---|---|---|
| GE2270A | Compound 2 | NAI003 | Erythromycin | Clindamycin | |
| ND062411 | ≤0.0018 | 0.03 | 0.015 | 0.03 | 0.06 |
| ND062511 | ≤0.0018 | 0.06 | 0.015 | 0.06 | 0.125 |
| ND062611 | ≤0.0018 | 0.06 | 0.06 | 0.06 | 0.06 |
| ND062711 | ≤0.0018 | 0.06 | 0.015 | 0.03 | 0.06 |
| ND062811 | ≤0.0018 | 0.06 | 0.015 | 0.03 | 0.06 |
| ND062911 | ≤0.0018 | 0.03 | 0.03 | 0.06 | 0.03 |
| ND063011 | ≤0.0018 | 0.03 | 0.007 | 0.06 | 0.5 |
| ND063111 | ≤0.0018 | 0.06 | 0.015 | 0.06 | 0.06 |
| ND063211 | ≤0.0018 | 0.03 | 0.015 | 0.06 | 0.06 |
| ND063311 | 0.0009 | 0.03 | 0.015 | >128 | 64 |
| L627 | ≤0.015 | NTa | 0.06 | NT | NT |
| ATCC 6919 | 0.008 | NT | 0.06 | NT | NT |
| ATCC 6922 | 0.03 | NT | 0.13 | NT | NT |
| ATCC 25746 | 0.03 | NT | 0.25 | NT | NT |
| L1559 | 0.008 | NT | 0.06 | NT | NT |
| L1560 | 0.015 | NT | 0.06 | NT | NT |
| L1561 | 0.015 | NT | 0.06 | NT | NT |
| L1562 | 0.008 | NT | 0.06 | NT | NT |
| L1563 | 0.008 | NT | 0.06 | NT | NT |
| L1564 | 0.015 | NT | 0.06 | NT | NT |
| L1565 | 0.015 | NT | 0.06 | NT | NT |
NT, not tested.