FIG 5.

Effect of chronic T. cruzi infection and drug treatment on spleen mass. At 74 dpi, mice were treated with benznidazole (100 mg/kg) (IBZ) or posaconazole (20 mg/kg) (IP1 and IP2 represent the Noxafil and HPMC-SV formulations, respectively) by the oral route, daily for 20 days (see also Fig. 1). Spleens were harvested and weighed at the end of the experiment. Spleen weights in infected, nontreated mice (INT) were significantly greater than those in noninfected mice (NI) (P < 0.0001) or infected mice which had been treated (P < 0.005, in each case).