TABLE 1.

Summary of drug efficacy against acute and chronic T. cruzi infections inferred from bioluminescence^a

Drug	Disease state	Treatment time (days)	Daily dose (mg/kg)	No. cured/no. tested
Benznidazole	Chronic	20	100	5/5
Benznidazole	Acute	20	100	5/5
Benznidazole	Chronic	10	100	6/6
Benznidazole	Chronic	5	100	6/6
Posaconazole	Chronic	20	20	0/9
Posaconazole	Acute	20	20	3/19

^aData were collated from the experiments illustrated in Fig. 1, 4, and 6. Mice were designated as cured only when bioluminescence negative by both in vivo and ex vivo imaging following immunosuppression (see Materials and Methods). In the posaconazole treatment, data from both formulations were pooled.