TABLE 4.
Amastigote and promastigote susceptibility of L. donovani upon MIL selection rounds
| L. donovani typea | MIL (μM) amastigote susceptibility (mean ± SEM) | AIb | MIL (μM) promastigote susceptibility (mean ± SEM) | AI |
|---|---|---|---|---|
| WT | 1.8 ± 0.4 | 1.7 ± 0.2 | ||
| P1 | 1.7 ± 0.2 | 0.9 (nsc) | NDd | |
| P2 | ND | ND | ||
| P3 | 3.6 ± 0.5 | 2.0e | 5.0 ± 0.5 | 2.9e |
a
WT, wild type; P1, after 1 drug treatment round; P2, after 2 drug treatment rounds; P3, after 3 drug treatment rounds.
b
IC50 values and corresponding AI were the result of at least three independent assays run in duplicate.
c
ns, nonsignificant.
d
ND, not done.
e
P < 0.001.