TABLE 1.
Antibiotic susceptibility for the three M. bovis BCG strains and H37Rv M. tuberculosis
| Antibiotic | MIC (μg/ml)a |
|||
|---|---|---|---|---|
| WT BCG | Δcpn60.1 | Δcpn60.1Comp | H37Rv | |
| Isoniazid | 0.1 | 0.1 | 0.1 | 0.1 |
| Rifampin | 0.05 | 0.01 | 0.05 | 1 |
| Ethambutol | 1 | 1 | 1 | 5 |
| Streptomycin | 0.2 | 0.2 | 0.2 | 1 |
| Ethionamide | 4 | 4 | 4 | 5 |
| Ciprofloxacin | 0.25 | 0.25 | 0.25 | 1 |
| Moxifloxacin | 0.05 | 0.05 | 0.05 | 0.25 |
| Teicoplanin | >1,000 | 17.5 | >1,000 | 100 |
| Vancomycin | >500 | 5 | >500 | 65 |
| Cerulenin | 0.75 | 0.75 | 0.75 | 2.5 |
a
The BacT/Alert MP system was used to determine the MIC more accurately. Δcpn60.1 Comp, the complemented Δcpn60.1 strain.