TABLE 3.
Synergistic interaction of carvacrol with ER stressors and the antifungals caspofungin and fluconazole
| Drug(s) (alone or in combination)a | MIC (μg/ml)b | FIC index |
|---|---|---|
| FCZ | 48 | |
| CRV | 28.12 | |
| FCZ-CRV | 12/3.51 | 0.37 |
| TNC | 1 | |
| CRV | 28.12 | |
| TNC-CRV | 0.06/7.03 | 0.31 |
| DTT | 93.7 | |
| CRV | 28.12 | |
| DTT-CRV | 23.4/3.51 | 0.36 |
| CSP | 0.5 | |
| CRV | 28.12 | |
| CSP-CRV | 0.06/3.51 | 0.24 |
| AmpB | 1 | |
| CRV | 28.12 | |
| AmpB-CRV | 0.5/14.06 | 1 |
a
CRV, carvacrol; FCZ, fluconazole; TNC, tunicamycin; DTT, dithiothreitol; CSP, caspofungin; AmpB, amphotericin B.
b
The MIC values for the individual drugs in a combination are separated by a slash.