TABLE 1.
Summary of the bactericidal effects of olanexidine against various bacterial strains by exposure time and MBCa
Strain tested (no. of strains) | Exposure time (s) | Minimal bactericidal concn (range) (μg/ml) for: |
||
---|---|---|---|---|
Olanexidine gluconate | Chlorhexidine digluconate | Povidone-iodine | ||
Gram-positive cocci except Enterococcus spp. (21) | 30 | 13.6 to 1,740 | 39.1 to >2,500 | ≤48.8 to 781 |
60 | ≤6.8 to 869 | 9.8 to >2,500 | ≤48.8 to 781 | |
180 | ≤6.8 to 434 | 9.8 to >1,250 | ≤48.8 to 391 | |
Enterococcus spp. (34) | 30 | 13.6 to 434 | 5,000 to >5,000 | 195 to >50,000 |
60 | ≤6.8 to 217 | 78.1 to >5,000 | 97.7 to >50,000 | |
180 | ≤6.8 to 54.3 | 9.8 to >5,000 | ≤48.8 to 1,560 | |
Gram-positive bacilli (9) | 30 | ≤6.8 to 1,740 | 19.5 to >2,500 | 97.7 to 781 |
60 | ≤6.8 to 1,740 | 19.5 to >2,500 | ≤48.8 to 781 | |
180 | ≤6.8 to 109 | 9.8 to >2,500 | 97.7 to 781 | |
Gram-negative strains except Burkholderia cepacia (34) | 30 | ≤6.8 to 869 | 39.1 to >5,000 | ≤48.8 to 3,130 |
60 | ≤6.8 to 434 | 19.5 to >5,000 | ≤48.8 to 781 | |
180 | ≤6.8 to 54.3 | ≤4.9 to 2,500 | ≤48.8 to 781 | |
B. cepacia (2) | 30 | >6,950 | >5,000 | 391 |
60 | 1,740 to >6,950 | >5,000 | 391 | |
180 | 434 | 625 | 195 |
The full data set is given in Table S1 in the supplemental material.