TABLE 4.
Protein-denaturing effects of olanexidine on hemoglobin by concentrationa
| Test substance | HDR% for concn (μg/ml) of: |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 9.8 | 19.5 | 39.1 | 78.1 | 156 | 313 | 625 | 1,250 | 2,500 | 5,000 | 10,000 | |
| Olanexidine gluconate | −1.5 ± 3.3 | −2.6 ± 2.9 | 0.7 ± 2.7 | 0.8 ± 2.5 | 15.0 ± 3.1 | 36.1 ± 1.9 | 45.3 ± 1.6 | 46.2 ± 1.3 | 47.8 ± 1.9 | 48.4 ± 1.6 | 47.7 ± 1.5 |
| Chlorhexidine digluconate | −0.1 ± 1.8 | 0.2 ± 1.1 | −1.8 ± 0.5 | −1.7 ± 1.9 | −1.2 ± 2.4 | −3.1 ± 2.3 | −2.4 ± 1.6 | −1.6 ± 1.8 | −0.9 ± 1.0 | −1.8 ± 2.3 | 4.4 ± 0.4 |
| Hexadecyl-pyridinium chloride monohydrate (positive control) (25) | 0.8 ± 1.2 | 5.9 ± 0.7 | 7.0 ± 0.8 | 20.8 ± 0.9 | 38.9 ± 0.8 | 38.5 ± 0.8 | 37.9 ± 1.0 | 37.4 ± 0.7 | 38.1 ± 0.7 | 38.5 ± 1.3 | 39.8 ± 1.1 |
a
Values represent the mean ± SD (n = 4).