TABLE 1.
Demographic, clinical, and laboratory characteristics of 162 hospitalized adults treated with intravenous AmB at a university hospitala
| Baseline variables | All (n = 162) | Type of AmB preparation |
P value | |
|---|---|---|---|---|
| Deoxycholate (n = 120) | Liposomal (n = 42) | |||
| Age (n = 161) (median [IQR]) (yr) | 35 (25–51) | 36 (24–51) | 33 (28–50) | 0.903 |
| Age quartiles (no. [%]) (yr) | ||||
| ≤25 | 43 (26.7) | 35 (29.4) | 8 (19.0) | 0.122 |
| 26–35 | 40 (24.8) | 24 (20.2) | 16 (38.1) | |
| 36–50 | 38 (23.6) | 30 (25.2) | 8 (19.0) | |
| >50 | 40 (24.8) | 30 (25.2) | 10 (23.8) | |
| Gender (no. [%]) | 0.187 | |||
| Male | 92 (56.8) | 64 (53.3) | 28 (66.7) | |
| Female | 70 (43.2) | 56 (46.7) | 14 (33.3) | |
| Residence (n = 160) (no. [%]) | 0.002 | |||
| Rural areas | 95 (59.4) | 61 (51.7) | 34 (81.0) | |
| Capital | 65 (40.6) | 57 (48.3) | 8 (19.0) | |
| AmB indication (no. [%]) | 0.000 | |||
| Teg. leishmaniasis | 33 (20.4) | 11 (9.2) | 22 (52.4) | |
| Visc. leishmaniasis | 12 (7.4) | 5 (4.2) | 7 (16.7) | |
| Suspected IFE | 26 (16.0) | 22 (18.3) | 4 (9.5) | |
| Confirmed IFE | 40 (24.8) | 34 (28.3) | 6 (14.3) | |
| FUO | 36 (22.2) | 34 (28.3) | 2 (4.8) | |
| Other | 15 (9.3) | 14 (11.7) | 1 (2.4) | |
| Charlson index (no. [%]) | 0.006 | |||
| 0–1 | 65 (40.1) | 40 (33.3) | 25 (59.5) | |
| 2–3 | 59 (36.4) | 51 (42.5) | 8 (19.0) | |
| ≥4 | 38 (23.5) | 29 (24.2) | 9 (21.4) | |
| Disease severity (no. [%])c | ||||
| Intensive care unit | 53 (32.7) | 48 (40.0) | 5 (11.9) | 0.002 |
| Vasopressor drugs | 35 (21.6) | 30 (25.0) | 5 (11.9) | 0.119 |
| Mechanical ventilation | 42 (26.1) | 38 (31.7) | 5 (11.9) | 0.022 |
| Serum lab values (median [IQR]) | ||||
| Cr (n = 162) (mg/dl) | 0.8 (0.7–1.1) | 0.8 (0.6–1.1) | 0.9 (0.8–1.1) | 0.350 |
| BUN (n = 103) (mg/dl) | 12.1 (7.9–18.2) | 12.6 (7.9–22.1) | 11.7 (10.3–14.5) | 0.088 |
| K+ (n = 98) (meq/liter) | 4.0 (3.6–4.4) | 3.9 (3.6–4.3) | 4.0 (3.6–4.5) | 0.906 |
| Mg2+ (n = 73) (mg/dl) | 1.8 (1.6–2.0) | 1.8 (1.6–2.0) | 1.8 (1.6–2.2) | 0.614 |
| HCO3− (n = 28) (meq/liter) | 21.6 (16.7–26.3) | 22.2 (17.7–26.2) | 18.7 (16.1–32.7) | 0.779 |
| Lactate (n = 23) (mmol/liter) | 1.6 (1.2–2.0) | 1.5 (1.2–2.0) | 2.0 (1.1–2.2) | 0.822 |
a
AmB amphotericin B.
b
Teg., tegumentary; Visc., visceral; IFE, invasive fungal infection; FUO, fever of unknown origin; BUN, blood urea nitrogen.
c
Intensive care unit, vasopressor drugs or mechanical ventilation reflect the need for these types of care at any point during the admission.