TABLE 2.
Pharmacokinetic properties of GS1 in calves following 4-day once-a-day i.v. bolus administration (4 mg/kg)
| PK parametera (units) | Mean (range)b on: |
|
|---|---|---|
| Day 1 | Day 4 | |
| AUC0–last (nM · h) | 14,649 (9,723–19,575) | 23,251 (12,433–34,069) |
| CL (liter/h/kg) | 0.58 (0.37–0.78) | 0.39 (0.17–0.61) |
| Vss (liter/kg) | 3.7 (3.1–4.3) | 3.1 (3.2–3.0) |
| MRTINF (h) | 6.8 (5.5–8.2) | 11.3 (5.2–17.5) |
| t1/2β (h) | 6.0 (4.8–7.3) | 9.0 (4.9–13.2) |
| Cmax (nM) | 3,180 (2,270–4,090) | 2,880 (2,180–3,580) |
| C8 (nM) | 606 (291–921) | 1,154 (358–1,950) |
| C24 (nM) | 123 (44–201) | 340 (55–624) |
a
The pharmacokinetic (PK) parameters are as follows: AUC0–last, area under the concentration-time curve over 24-h dosing interval; CL, plasma clearance; Vss, volume of distribution at steady state; MRTINF, mean residence time; t1/2β, elimination half-life at β phase calculated from the slope of the terminal phase; Cmax, maximal concentration; C8, concentration at the 8-h time point; C24, concentration at the 24-h time point.
b
The mean (range) values for two animals are given.