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Drug concentrations in different compartments at 24 h following administration of GS1 (4 mg/kg i.v. bolus) to healthy calves
| Compartment or sample | GS1 concn (μM) at 24 ha | Ratio to plasmab |
|---|---|---|
| Plasma | 5.8 | 1.0 |
| Nasal swab | 78c | 4.0 |
| BALF | 88 | 15 |
| Lung tissue | 1,140 | 195 |
Mean values for two animals.
Ratio of the GS1 concentration in the compartment or sample compared to the GS1 concentration in plasma.
At the 12-h time point.
